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Does Anafranil Make You Last Longer in Bed?

Yes, Anafranil makes you last longer in bed by delaying orgasm. It is scientifically proven to delay ejaculation in men and is used for the treatment of premature ejaculation (PE) besides OCD.

But is Anafranil (clomipramine) safe to use? Does Anafranil make you last longer in bed without any side effects? Should you use it?

Probably not.


Keep reading to find out…

What is Anafranil?

Anafranil (also known as clomipramine) is an antidepressant used for the treatment of obsessive-compulsive disorder (OCD) which is a common disorder where the patient has uncontrollable and recurring thoughts and/or behaviors.

ocd cycle

Clomipramine is a tricyclic antidepressant that works by restoring your brain’s balance by optimizing the production and release of substances such as serotonin. It minimizes unwanted thoughts and the urge to perform repeated tasks. It helps in the management of feelings, thoughts, mood, and behaviors by balancing substances and chemicals in your brain.

Anafranil Uses

Clomipramine isn’t just used to treat OCD, it has a lot of other uses too. It is used off-label to treat several disorders including:

  • Depression and anxiety
  • Insomnia
  • Trichotillomania
  • Neuropathic and chronic pain
  • Panic disorder
  • Cataplexy syndrome
  • Premature ejaculation.

Anafranil Side Effects

The common side effects of clomipramine include:

  • Dizziness and drowsiness
  • Constipation
  • Mouth dryness
  • Nausea and vomiting
  • Stomach issues
  • Excessive sweating
  • Blurred vision
  • Anxiety and restlessness
  • Insomnia
  • Reduction in sex drive
  • Trouble having an orgasm.

Does Anafranil Make You Last Longer in Bed?

Yes, Anafranil makes you last longer in bed. A common side effect of Anafranil is that it delays orgasm and makes it hard to ejaculate. It is commonly used off-label to treat premature ejaculation.

Clomipramine increases the amount of serotonin in your brain which helps maintain the balance of your brain leading to a reduction in unwanted thoughts and behaviors. The medicine, in doing so, releases chemicals in your brain that interfere with the ejaculatory reflex leading to a delay in orgasm.

This is a reason Anafranil is used for the treatment of premature ejaculation like other antidepressants (SSRIs) as discussed in this article

Several clinical studies reported that clomipramine significantly delays ejaculation during sexual intercourse.

Participants in one study took 25 mg of clomipramine 12 to 24 hours before sexual activity. It increased ejaculation duration by 2 to 8 minutes with no major side effects. However, men who were suffering from both premature ejaculation and erectile dysfunction didn’t see any improvement in ejaculation duration (latency to ejaculation).

In a follow-up study, authors reported that if 25 mg clomipramine on-demand is ineffective, PE patients should take 30 mg clomipramine daily for better results. The average ejaculation duration of the participants who took clomipramine 30 mg increased from 25 seconds to 220 seconds. The participants who took 30 mg clomipramine daily found it more effective than 25 mg clomipramine on-demand before sexual intercourse. 

Another study lasted for 12 weeks where participants took a 15 mg clomipramine tablet 2 to 6 hours before intercourse. The ejaculation duration increased significantly and the authors reported on-demand clomipramine to be an effective premature ejaculation treatment. The participants reported nausea and dizziness as the two major side effects.

Two more studies reported the effectiveness of Anafranil for the treatment of premature ejaculation and compared it with SSRIs in terms of effectiveness. 

A 2021 systematic review analyzed 14 randomized controlled trials and found that Anafranil significantly increases ejaculation duration with higher doses resulting in more delay in orgasm. The authors concluded that PE patients can take up to 50 mg Anafranil dose and they won’t experience any serious side effects.

These studies show that Anafranil does make you last longer in bed without any serious issues. The maximum allowed dose is 50 mg and it can be taken on-demand (as required) or daily.

Should You Use Clomipramine to Last Longer in Bed?

Yes, Anafranil is used off-label for the treatment of premature ejaculation so you can use it to last longer in bed. But it is a prescription medicine that only a licensed physician can prescribe you.

There is, unfortunately, no FDA approved drug for premature ejaculation. Physicians and sexologists prescribe off-label medicines to men for lasting longer in bed (off-label use of medicine means using it for a condition other than for which it is approved).

Antidepressants that belong to the selective serotonin reuptake inhibitors (SSRIs) class are majorly used for the treatment of PE as they don’t have severe side effects. A study reported that paroxetine (an SSRI) increases ejaculatory duration by 9 times. Another study analyzed different SSRIs for the treatment of premature ejaculation and found most of them extremely effective and helpful in delaying orgasm. 

Tricyclic antidepressants (Anafranil), on the other hand, have similar effects and are equally helpful for lasting longer in bed. But since they have more severe side effects than SSRIs, they aren’t the first choice for the treatment of PE.

There are two instances when your physician might prescribe you a tricyclic antidepressant:

  1. SSRIs didn’t work for you and you now need a stronger, more effective medicine
  2. In most cases, an SSRI is used in combination with Anafranil to boost ejaculation duration as studies have shown that these two antidepressants get more effective when used together for lasting longer in bed.

So, you can use clomipramine to last longer in bed as it is used off-label for it. But you can’t use it yourself as it is a prescription medicine. Your doctor will know when to prescribe you Anafranil.

Is Anafranil Approved by the FDA for PE?

No, Anafranil is not approved by the FDA for the treatment of premature ejaculation. The FDA has not approved any medicine for PE.

Doctors prescribe off-label prescription medicines to their patients for delaying orgasm. The most common drug that a physician is most likely to prescribe for delaying climax is an antidepressant. This includes both SSRIs and tricyclics.


Because all antidepressants have a common side effect that they make you last longer in bed. Several studies reported that antidepressants (including Anafranil) offer an effective cure for premature ejaculation with minimal side effects.

While Anafranil isn’t approved by the FDA for PE, it can be used to last longer in bed.


Does Anafranil cause erectile dysfunction?

Yes, Anafranil can cause erectile dysfunction as it is scientifically known to have adverse sexual effects. A study reported that 26% of men experienced negative sexual side effects after using Anafranil (clomipramine).

Can clomipramine be used in erectile dysfunction?

No, clomipramine can’t be used if you have erectile dysfunction. It does not work for men who are suffering from erectile dysfunction as reported in multiple studies. 

How long does Anafranil take to work?

If you are taking Anafranil for OCD, it will take 2 to 3 weeks before you will notice positive change and improvement. If you are taking it to last longer in bed, it takes 2 to 4 hours to work. You can take Anafranil on-demand 2 to 4 hours before intercourse.

Can I take Anafranil and Viagra together?

Yes, you can take both together. Viagra is often prescribed with Anafranil to offset the negative impact of Anafranil on erection. Viagra helps you overcome erectile dysfunction caused by Anafranil. 

Anafranil for Premature Ejaculation

Anafranil (clomipramine) isn’t just used for treating OCD. It has other uses too (mostly off-label). It is scientifically proven in multiple clinical trials as an effective medicine for curing premature ejaculation in men.

Like other antidepressants, it delays orgasm as a side effect. This makes it an ideal medicine for men who are suffering from PE. It works on-demand as well as in the form of a daily dose. Anafranil up to 50 mg is considered safe for lasting longer in bed.

You can’t take clomipramine yourself to delay orgasm. It is a prescription medicine and shouldn’t be used without a valid medical prescription as it might adversely impact sexual function including erectile dysfunction.

Consult your doctor if you think you are suffering from premature ejaculation and need a drug to last longer in bed.

If you are not suffering from PE and just want to last longer in bed to have more pleasure and fun. You should look for other safer methods like desensitizing products. Antidepressants are way too harmful and should be avoided whenever possible.

Check out this article for the best desensitizing products that you can easily purchase online and last longer in bed without any side effects.

Staying safe should be your top priority.